Chapter 1. Requiem of the Wraith

Difficulty 1: Chronol, TT1-1 (TT60), 60+

Boss	Substance	Green Drops	Gold Drops	Comments
Chintien	1	Chintien's Edge	NA	Earth, physical and magic attacks. No AoE. His attack does not change based on mode and boss settings.
Lord of Percussion	1	Broken Drums	NA	Single Mode: Physical attack, no AoE. Squad Mode: Once his HP is less than 50%, he will unleash strong physical damage AoE. Cleric is a must with blue bubble.

There are 3 more bosses in High Settings but they don't drop any TT mats for TT60 so don't waste your ultimate substance by selecting High Boss settings.

But, for Quest Wraith's Ploy you must go 1-1 high to complete it. This will be the only time you will have to use a ultimate Substance in 1-1

Difficulty 2: Dimensic, TT1-2 (TT70), 68+

Boss	Substance	Green Drops	Gold Drops	Comments
Chintien	No	Chintien's Armor Shard	NA	Earth, physical and magic attacks. No AoE. His attack does not change based on mode and boss settings.
Lord of Percussion	No	Framework of Drum	NA	Single Mode: Physical attack, no AoE. Squad Mode: Once his HP is less than 50%, he will unleash strong physical damage AoE. Cleric is a must with blue bubble. (When his health is 363,000 he will start AOEing)
Soulbanisher	1	Soulgatherer's Tentacles	NA	Unleashes very strong long-ranged AoE when his HP is under 50%. Must have at least 2 clerics and a real tank (being above the level 70). Venos be careful and watch your pet's HP, level 10 pet heal is not enough to keep pet alive. Trick is to stow pet before it dies. Recall pet again in between AoE blast from Soulbanisher and quickly heal it. He also likes to reset aggro when his HP under 50%, so all party members (including cleric) should have enough HP/def to survive one his magic hit on BB. (Only appears in 1-2 High Mode)
Dimentora	1	Broken Shard of Gold Armor	NA	Short-ranged AoE. When you first find this boss, he will be on a platform in the middle of the room. It is strongly recommended that your tank lure him off this podium and to the side of the room - at about 80% health, he will call forth four "DaVinci" which march around his platform (they drop nothing, and give no experience. Do not bother killing them). After 10 minutes, he will reset agro, calling out to "Twilight007" - this also summons a fifth DaVinci (appropriately named Twilight 007) in the center of the platform. Be sure to have all DDs and cleric halt or slow attack/healing until the tank has securely regained aggro. Also Venomancer shouldn't use pet while reset-time. Dimentora's AOE is channeled visibly, and easily interrupted.
Vipenalt	1	Ancient's Serpent Skin	NA	Wood damage. No AoE. While killing, Vipenalt will summon numerous Clapping Hands in the room. In order to not set them off, everyone in the room MUST remain stationary (can still attack, though, of course). An alternative way to killing this boss, to avoid the Hands, is to have the tank lure him outside onto the walkway that circles Dimentora's platform. Veno can easily tank with herc. (Only appears in 1-2 High Mode)

Difficulty 3: Substancia, TT1-3 (TT80), 76+

Boss	Substance	Green Drops	Gold Drops	Comments
Chintien	No	Chin's Plate	NA	Vide: 1-2
Lord of Percussion	No	War Drum	NA	Vide: 1-2
Soulbanisher	1*	Soulgatherer's Mirror	NA	Vide: 1-2
Shooting Aur (Dimentora)	1*	Tough Shard of Gold Armor	Golden Spirit	Vide: 1-2
Vipenalt	1*	Ancient's Serpent Blood	Ancient Serpent's Orb	Vide: 1-2

^* in single mode need 2 substance